Tesamorelin 5mg
Product Description:
Tesamorelin 5mg is a synthetic peptide known as a growth hormone-releasing hormone (GHRH) analogue. It is used to decrease the amount of extra fat in the stomach area in adults who have lipodystrophy (increased body fat in certain areas of the body) It is available as a sterile lyophilized powder for injection. Each vial contains 5 milligrams (mg) of Tesamorelin.
Pharmacological Properties for: Tesamorelin
Tesamorelin is a synthetic peptide with distinct pharmacological properties that have garnered attention in both research and potential therapeutic applications. This peptide is one of few approved for use by the FDA for HIV patients who suffer from lipodystrophy
Growth Hormone Release Stimulation: Tesamorelin functions as an analogue of the growth hormone-releasing hormone (GHRH). By mimicking GHRH, Tesamorelin stimulates the pituitary gland to release growth hormone (GH). This action leads to elevated circulating levels of GH, which influences various physiological processes.
Selective Action: One notable feature of Tesamorelin is its selective action on GHRH receptors, which facilitates GH release without significantly affecting other hormonal pathways. This selectivity helps minimize unintended effects on other systems.Tesamorelin is in a class of medications called human growth hormone-releasing factor (GRF) analogs. It works by increasing the production of a certain natural substance that can decrease the amount of body fat. It has an affinity to help reduce increased fat in the upper back and stomach areas leading to rapid fat distribution changes.
Growth Promotion: The primary pharmacological effect of Tesamorelin is its ability to enhance the release of growth hormone. Increased GH levels can have anabolic effects on tissues such as muscle, bone, and connective tissues, which has led to interest in its potential use for promoting growth and muscle development.
Metabolic Effects: Elevated GH levels influenced by Tesamorelin can impact metabolism. GH plays a role in regulating metabolism by promoting the breakdown of fats, protein synthesis, and glucose homeostasis.
Recovery and Repair: The growth-promoting effects of Tesamorelin are of interest in tissue repair and recovery processes. Increased GH levels can contribute to tissue regeneration and healing, particularly in cases of injury or stress.
Combination with Other Peptides: Tesamorelin is often used in combination with other peptides, hormones, or growth factors. Its synergistic effects with other compounds can enhance its overall impact on growth promotion, metabolism, and other physiological processes.
Clinical Applications: The pharmacological properties of Tesamorelin have led to research into its potential therapeutic applications. These include treating conditions related to growth deficits, muscle wasting, and certain metabolic disorders, such as excess abdominal fat in HIV patients. Clinical research is ongoing to better understand its full range of effects.
Important Note: Tesamorelin’s pharmacological properties are intricate and multifaceted. While this information provides an overview of its potential effects, it’s essential to consult scientific literature and qualified healthcare professionals for the most accurate and up-to-date information on this peptide’s pharmacology.
Pharmacokinetic Properties for: Tesamorelin
Tesamorelin is a synthetic peptide with unique pharmacokinetic characteristics that influence its absorption, distribution, metabolism, and elimination within the body.
Absorption: Tesamorelin is typically administered via subcutaneous injection. Upon injection, it enters the bloodstream and circulates to target tissues, particularly the pituitary gland. The rate and extent of absorption can be influenced by factors such as injection site, formulation, and individual variations.
Distribution: Once absorbed into the bloodstream, Tesamorelin is distributed throughout the body. Its distribution pattern reflects its mechanism of action, which involves binding to specific receptors on the surface of cells in the pituitary gland, leading to the release of growth hormone.
Metabolism: Tesamorelin undergoes metabolic processes within the body. Enzymes in various tissues may contribute to the breakdown of the peptide into smaller fragments or metabolites. The specifics of Tesamorelin’s metabolism are areas of ongoing research.
Elimination: The elimination of Tesamorelin primarily occurs through renal excretion, with the kidneys playing a significant role in clearing the peptide from the bloodstream. The rate of elimination contributes to the overall duration of the peptide’s effects.
Half-Life: The half-life of Tesamorelin can vary based on factors such as dosage, route of administration, and individual characteristicsThe half-life of tesamorelin is short, estimated at 26–38 min, yet effects to stimulate pituitary secretion were still clearly seen after 2 weeks.
Dosage and Administration Frequency: The most common Tesamorelin dosage is 1-2mg per day. It is most ideal to take in the evenings atleast 1 hour after meals and best to extend treatment for a minimum period of 90 days to 180 days.
Clinical Implications: Understanding the pharmacokinetic properties of Tesamorelin is crucial for optimizing its therapeutic use and minimizing potential side effects. Its absorption, distribution, metabolism, and elimination profile play a role in determining how the peptide is dosed and administered.
Important Note: This information provides a general overview of the pharmacokinetic properties of Tesamorelin. For specific details and the most up-to-date information on this peptide’s pharmacokinetics, it’s advisable to consult scientific literature and qualified healthcare professionals.
Indications: Tesamorelin 5mg is primarily indicated for:
- Reducing excess abdominal fat in patients with lipodystrophy
- Stimulating the release of growth hormone
- Supporting muscle growth and recovery
Contraindications: Tesamorelin 5mg is contraindicated in individuals who:
- Have a known allergy to Tesamorelin or any of its components
- Have a history of cancer or are currently undergoing cancer treatment
- Have severe cardiovascular disease
- Are pregnant or breastfeeding
Dosage and Administration: The dosage of Tesamorelin can vary based on individual factors and the healthcare provider’s recommendation. It is typically administered via subcutaneous (SC) injection. Here are general dosage guidelines:
Growth Hormone Stimulation:
- The recommended dosage ranges from 1 mg per injection.
- Injections are typically given once daily, depending on the desired effect and the healthcare provider’s guidance.
Adverse Reactions: Adverse reactions to Tesamorelin 5mg are generally mild and can include:
- Injection site discomfort
- Increased appetite
- Water retention
- Flushing
- Muscle pain
Serious adverse reactions are rare but may include allergic reactions or changes in blood glucose levels.
Storage Instructions: Store Tesamorelin 5mg vials in a dry place at room temperature (between 2°C and 8°C before and after reconstitution). Transport and temporary storage at room temperature should be kept to less than 96 hours. Store reconstituted peptide between 2°C and 8°C at all times. Protect from light.
Preparation and Administration:
- Reconstitute the lyophilized powder with the provided sterile diluent according to the manufacturer’s instructions.
- Gently swirl the vial until the powder is completely dissolved.
- Draw up the appropriate dose using a sterile syringe.
- Administer the injection into the subcutaneous tissue, following the healthcare provider’s recommendations.
Important Note: Tesamorelin should only be used under the supervision of a qualified healthcare provider. It is important to follow the prescribed dosage, administration, and monitoring plan for optimal results and to minimize the risk of adverse effects. Always consult a healthcare provider before starting any new medication or treatment.
