Raloxifene (brand name Evista) is a selective estrogen receptor modulator (SERM) that is used primarily in the treatment and prevention of osteoporosis in postmenopausal women. It is also used off-label to reduce the risk of breast cancer in high-risk women.
Raloxifene works by binding to estrogen receptors in the body and mimicking the effects of estrogen in some tissues, while blocking the effects of estrogen in others. This action can help to increase bone density and reduce the risk of fractures, as well as reducing the risk of breast cancer.
Benefits of Raloxifene
The main benefit of Raloxifene is its ability to increase bone density and reduce the risk of fractures in postmenopausal women with osteoporosis. It can also reduce the risk of breast cancer in high-risk women. Additionally, Raloxifene has been shown to improve cholesterol levels and reduce the risk of cardiovascular disease.
Dosage Instructions
The recommended dose of Raloxifene for osteoporosis treatment and prevention is typically 60 mg per day, taken as a single dose or divided into two doses. The recommended dose for breast cancer risk reduction is also 60 mg per day. It is important to follow the dosage instructions provided by a healthcare provider.
Side Effects
Raloxifene can cause some side effects, which may include hot flashes, leg cramps, and increased risk of blood clots. Rare but serious side effects can include stroke and deep vein thrombosis. Women with a history of blood clots, stroke, or liver disease should discuss the risks and benefits of Raloxifene with their healthcare provider before starting treatment.
Half-life
The half-life of Raloxifene is approximately 27 hours. This means that it takes this amount of time for half of the drug to be eliminated from the body. As a result, it is usually taken once a day to maintain steady levels in the bloodstream.
In conclusion, Raloxifene is an effective treatment for osteoporosis in postmenopausal women and can also reduce the risk of breast cancer in high-risk women. However, it is important to follow the dosage instructions provided by a healthcare provider and be aware of the potential side effects. Women with a history of blood clots, stroke, or liver disease should discuss the risks and benefits of Raloxifene with their healthcare provider before starting treatment.
