Product Name: Somatropin 40 IU Pen
Generic Name: Somatropin (Recombinant Human Growth Hormone)
Dosage Form: Injectable Solution
Composition: Each Somatropin 40 IU Pen contains 40 international units (IU) of recombinant human growth hormone (Somatropin), along with excipients necessary for reconstitution and stability.
Pharmacological Properties for Somatropin 40 IU Pen: Somatropin, with 40 international units (IU) of Recombinant Human Growth Hormone (rHGH) with significant pharmacological properties that affect growth, metabolism, and cellular functions.
Key Properties:
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- Growth Promotion: Somatropin is used to stimulate linear growth during childhood and adolescence. It targets specific receptors in the epiphyseal growth plates of long bones, promoting the proliferation of chondrocytes and osteoblasts, leading to increased bone length and overall stature.
- Stimulation of Protein Synthesis: Somatropin enhances protein synthesis in different tissues, including muscles, by activating cellular signaling pathways. This aids in tissue repair, growth, and maintenance.
- Metabolic Effects: Somatropin influences metabolism by breaking down triglycerides in adipose tissue and increasing the availability of free fatty acids for energy utilization. It also enhances glucose uptake by cells, contributing to improved lipid metabolism and reduced insulin sensitivity.
- Stimulation of IGF-1 Production: Somatropin triggers the production of insulin-like growth factor-1 (IGF-1) in the liver and other tissues. IGF-1 plays a vital role in mediating the effects of growth hormone on cell growth, differentiation, and metabolism.
- Connective Tissue and Organ Growth: Somatropin supports the development and maintenance of connective tissues, tendons, and ligaments. It contributes to the optimal function of various organs and tissues.
- Bone Mineralization: Indirectly, Somatropin impacts bone mineralization by promoting the differentiation and activity of osteoblasts, the cells responsible for bone formation. This strengthens bone structure.
- Immune System Modulation: Emerging research suggests that Somatropin might influence immune system regulation, affecting immune cell function and cytokine production.
Clinical Applications: Somatropin 40 IU Pen is used in various clinical scenarios, including:
- Treatment of growth hormone deficiency in children and adults
- Management of short stature in pediatric patients with various conditions
- Supportive therapy in chronic kidney disease-associated growth impairment
- Treatment of Turner syndrome, Prader-Willi syndrome, and other growth-related disorders
- Anti-aging and wellness
- Generalized fat-loss
- Muscle gain (hyperplasia)
Pharmacokinetic Properties for: Somatropin
- Somatropin, a synthetic form of human growth hormone, exhibits distinct pharmacokinetic characteristics that impact its absorption, distribution, metabolism, and elimination within the body.
- Absorption: Somatropin is typically administered via subcutaneous injection. Upon injection, it enters the bloodstream and circulates to target tissues. The rate and extent of absorption can vary based on factors such as injection site, formulation, and individual variations.
- Distribution: Once absorbed into the bloodstream, Somatropin is distributed throughout the body. It interacts with specific receptors on target cells, including those in bones, muscles, and other tissues. Its distribution reflects its mechanism of action, which involves stimulating growth and influencing metabolism.
- Metabolism: Somatropin undergoes metabolic processes within the body. The liver plays a central role in metabolizing Somatropin into smaller peptides and amino acids. These breakdown products can then exert various physiological effects.
- Elimination: The elimination of Somatropin primarily occurs through hepatic clearance and renal excretion. The kidneys play a role in removing metabolites and unbound peptides from the bloodstream. The rate of elimination contributes to the overall duration of the peptide’s effects.
- Half-Life: The half-life of Somatropin can vary based on factors such as dosage, administration route, and individual characteristics. It typically ranges from around 2 to 4 hours. Due to its relatively short half-life, Somatropin often requires multiple administrations to maintain its effects over time.
- Dosing Frequency: Due to its short half-life, Somatropin necessitates frequent administration to achieve sustained therapeutic levels. The dosing frequency can vary based on the specific medical indication, desired therapeutic outcome, and patient’s age.
- Clinical Implications: Understanding the pharmacokinetic properties of Somatropin is essential for optimizing its therapeutic use and minimizing potential side effects. Its absorption, distribution, metabolism, and elimination profile play a role in determining how the peptide is dosed and administered.
- Important Note: This information provides a general overview of the pharmacokinetic properties of Somatropin. For specific details and the most up-to-date information on this peptide’s pharmacokinetics, it’s advisable to consult scientific literature and qualified healthcare professionals.
Indications: Somatropin 40 IU Pen is indicated for:
- Treatment of pediatric patients with growth failure due to inadequate secretion of endogenous growth hormone.
- Replacement of growth hormone in adult patients with growth hormone deficiency.
Contraindications: Somatropin 40 IU Pen is contraindicated in patients with:
- Active malignancy
- Closed epiphyses
- Hypersensitivity to somatropin or any excipients
- Acute critical illness after specific surgeries or acute respiratory failure
- Prader-Willi syndrome with severe obesity or respiratory impairment
Warnings and Special Precautions:
- Evaluate patients with ongoing epiphyseal closure or evidence of bone growth cessation.
- Monitor thyroid function, glucose tolerance, and intracranial pressure.
- Assess Turner syndrome patients for otitis media and monitor those with a history of scoliosis.
Adverse Reactions: Common adverse reactions include local injection site reactions, headache, edema, arthralgia, and myalgia.
Dosage and Administration: Somatropin 40 IU Pen should be administered via subcutaneous injection. The dose and administration regimen should be individualized based on patient characteristics and indication. The pen candispense in 1-8 iu doses by selecting the required dosage on the pen selector.
Storage Instructions: Store Somatropin 40 IU Pen in a cool, dry place at between 2°C and 8°C. Transport and temporary storage at room temperature should be kept to less than 96 hours. Protect from light.
Package Contents: Each package contains one Somatropin 40 IU Pen, including 8 x single use disposable needles for administration. Additional single use disposable needles can be purchased at your local pharmacy.
This information serves as a general overview of Somatropin 40 IU Pen. For specific dosing instructions, contraindications, and precautions, please refer to a qualified healthcare professional.
